Eosinophilic Esophagitis (EoE) is a chronic inflammatory condition of the esophagus, the tube that connects the mouth to the stomach. It is characterized by an increased number of eosinophils, a type of white blood cell, in the esophageal lining.

EoE symptoms can vary widely and may include: Abdominal pain, Difficulty swallowing (dysphagia), Chest pain or heartburn, Food impaction, Nausea and vomiting, Regurgitation.

Immunology is the study of the immune system and is a very important branch of the medical and biological sciences. The immune system protects us from infection through various lines of defense. If the immune system is not functioning as it should, it can result in disease, such as autoimmunity, allergy and cancer. It is also now becoming clear that immune responses contribute to the development of many common disorders not traditionally viewed as immunologic, including metabolic, cardiovascular, and neurodegenerative conditions such as Alzheimer’s.

Is our cell line of choice when performing experiments. It is an extensively characterized telomerase-immortalized, non-transformed human esophageal epithelial cell line. This cell line has been validated and used extensively in EoE research at our institution among others.

Food protein-induced enterocolitis syndrome (FPIES) is a rare food allergy that affects the gastrointestinal (GI) tract. Unlike most food allergies, symptoms of FPIES do not begin immediately after eating. Instead, it can take hours before severe symptoms begin.

The most common FPIES food triggers are cow’s milk, soy, rice and oats, but any food can cause FPIES symptoms. These symptoms can lead to other complications, including changes in blood pressure and body temperature, lethargy, and failure to thrive.

 The analysis of a single or a small number of genes at once to the investigation of thousands of genes, going from the study of the units of inheritance to the investigation of the whole genome of an organism. The science of the genomes, or “genomics,” initially dedicated to the determination of DNA sequences (the nucleotide order on a given fragment of DNA), has promptly expanded toward a more functional level–studying the expression profiles and the roles of both genes and proteins.